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Types of Fasting

Previously we introduced the concept and definition of fasting, as well as a brief description of the types of fasting.  Here we will go into greater depth about these types so you know the pros and cons:


In lay terms, fasting is the omission of food. However, it truly is much more than just that! What are the benefits of fasting? What determines the fasting state is actually a combination and quantity of the specific macro- and micronutrients of the foods we eat. Luckily, there is more than one way to fast, but there is only one that has been shown to induce rejuvenation and regeneration.1

Time Restricted Feeding (TRF)

TRF is a form of intake restriction, specifically focused on the when and how long eating occurs rather than macronutrients.2,3 This type of fasting is based off of the theory that our ancestors likely fed during daylight with limited resources and fasted during the night. Interestingly, this is controlled by what we call the circadian system. The circadian system oscillates every ~24 hours in a rhythm that enables organisms to respond to the light-dark cycle, which coincides with food accessibility. Today, this system has been disrupted due to long work hours, artificial light exposure, and haphazard eating behavior. To get back control of this system, we can mimic the natural circadian pattern by restricting feeding to a certain period of time.

As far as benefits of fasting and TRF specifically, preclinical trials have been positive, but clinical trials are inconsistent.


  • Reduction in body weight, total cholesterol, triglycerides, glucose, insulin, inflammatory markers, insulin resistance


  • Fat mass decrease, muscle mass retention, IGF-1 decrease, adiponectin increase, total leptin decrease (when adjusted for fat mass, this did not change)
  • Decreased body weight (inconsistent), triglycerides, glucose, LDL

How to Intermittent Fast | Benefits of Fasting

Intermittent Fasting (IF) – How to Intermittent Fast

Intermittent fasting is a form of fasting where the individual will fast for an interval of time, usually no more than 48hrs, and then eat normally for the remaining period of time per week. The most common example of this is known as the “5:2” diet, where the individual restricts calories for 2 days, consecutive or not, and then eats normally for the remaining 5 days.

For the most part, the preclinical trials have shown positive results, but clinical trials have been mixed.


  • Reduction in body weight, glucose, insulin, inflammation, myocardial tissue damage, and leptin; elevation of adiponectin levels


  • Maintenance of healthy levels of blood glucose
  • Increased metabolism of fatty acids and ketones
  • Lower adherence rates compared to daily caloric restriction
  • No comparable difference between alternative day fasting versus daily caloric restriction regarding: weight loss, fat mass loss, blood pressure, cholesterol, insulin sensitivity, inflammation

Periodic Fasting

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