Periodic fasting is simply fasting for a periodic time; usually, this is anywhere from 4 to 7 days. The overarching goal of periodic fasting is to induce the stress of fasting onto the body for a period of time in order to induce the stress resistant mechanisms in the body to combat future stressors1,9. An example of a periodic fast would be either a water fast for 5 days or a fasting mimicking diet for 5 days.
As far as the preclinical trials go, the results are promising. The same can be said for the clinical trials.
- Extend lifespan, induce stress resistance, and promote visceral fat loss
- Induce stem cell proliferation
- Promote cellular regeneration and rejuvenation
- Improve cognitive performance
- Maintain healthy levels of glucose, triglycerides, LDL, total cholesterol, diastolic blood pressure, insulin-like growth factor-1, and insulin
Promote weight loss (specifically visceral adiposity) while preventing lean body mass loss
Ultimately, there are multiple ways to fast, but it seems that there are ways to optimize this process. Specifically, if you eat within a certain window of time, it appears that we can gain many benefits from simply eating whenever we want to – which makes sense. Not everything is meant to be function at all times and resting is important! It is almost like a car; imagine if you kept the engine on all day, every day for weeks on end. It is sure to break far sooner than if you were to drive it normally. The same can be said with the body. But not only does the timing of meals seem to be important, but also the duration of the fast. It seems that the body takes a little time to initiate a response and needs to be in the “fasting” state for at least 4 days in order to gain the benefits after the fast is over.
- Brandhorst et al., A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan, Cell Metabolism (2015), http://dx.doi.org/10.1016/j.cmet.2015.05.012
- Longo VD, Panda S. Fasting, circadian rhythms, and time restricted feeding in healthy lifespan. Cell metabolism. 2016;23(6):1048-1059. doi:10.1016/j.cmet.2016.06.001.
- Mattson MP, Allison DB, Fontana L, et al. Meal frequency and timing in health and disease. Proceedings of the National Academy of Sciences of the United States of America. 2014;111(47):16647-16653. doi:10.1073/pnas.1413965111.
- Rothschild J, Hoddy KK, Jambazian P, Varady KA. Time-restricted feeding and risk of metabolic disease: a review of human and animal studies. Nutr Rev. 2014 May;72(5):308-18. doi: 10.1111/nure.12104. Epub 2014 Apr 16.
- Moro T, Tinsley G, Bianco A, et al. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. Journal of Translational Medicine. 2016;14:290. doi:10.1186/s12967-016-1044-0.
- Wan, R., Ahmet, I., Brown, M., Cheng, A., Kamimura, N., Talan, M., Mattson, M.P.,2010. Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats. J. Nutr. Biochem. 21, 413–417.
- Johnson, J.B., Summer, W., Cutler, R.G., Martin, B., Hyun, D.H., Dixit, V.D., Pearson,M., Nassar, M., Telljohann, R., Maudsley, S., Carlson, O., John, S., Laub, D.R., Mattson, M.P., 2007. Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic. Biol. Med. 42, 665–674.
- Trepanowski JF, Kroeger CM, Barnosky A, Klempel MC, Bhutani S, Hoddy KK, Gabel K, Freels S, Rigdon J, Rood J, Ravussin E, Varady KA. Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial. JAMA Intern Med. 2017 Jul 1;177(7):930-938. doi: 10.1001/jamainternmed.2017.0936.
- Fontana L, Partridge L, Longo VD. Dietary Restriction, Growth Factors and Aging: from yeast to humans. Science (New York, NY). 2010;328(5976):321-326. doi:10.1126/science.1172539.
- Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 Feb 15;9(377). pii: eaai8700. doi: 10.1126/scitranslmed.aai8700.